RNA interference

RNA interference (RNAi) is a system within living cells that helps to control which genes are active and how active they are. Two types of small RNA molecules – microRNA (miRNA) and small interfering RNA (siRNA) – are central to RNA interference. RNAs are the direct products of genes, and these small RNAs can bind to specific other RNAs and either increase or decrease...
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Also known as:

  • RNAi

Biology

Broader Group:

Data Source:

  • gene_ontology.obo

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Description:

  • The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes.

Identifier:

  • GO:0016246

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Award-Winning Work

Awards Won:

Year Award Award Winner (e.g. a person or organization) Notes/Description
  • 2006
  • "for their discovery of RNA interference - gene silencing by double-stranded RNA"
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